Low doses of ACE inhibitors and AT1 blockers have a synergistic effect but high doses are less than additive
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چکیده
منابع مشابه
Review: high doses of antipsychotic drugs are no more or less effective than medium doses in people with schizophrenia.
Study selection and analysis: Double blind, randomised controlled trials of people with schizophrenia or schizoaffective disorder comparing two or more doses of typical or atypical antipsychotics were eligible. Dose response curves were plotted and the median effective dose, defined as 50% of the maximum response (ED50), and the near maximal effective dose range (ED85 to ED95) was established f...
متن کاملComparing the Efficacy of High and Low Doses of Vitamin A in Prevention of Bronchopulmonary Dysplasia
Background Bronchopulmonary dysplasia (BPD) is one of the most common serious squeal of preterm infants. It involves approximately one quarter of infants with birth weight less than 1500 grams and 30% of less than 1000 grams. Vitamin A has been shown to reduce BPD rate. We compared efficacy of low and high doses of vitamin A for prevention of BPD in very low birth weight preterm infants. Materi...
متن کاملA PROSPECTIVE, RANDOMIZED, CONTROLLED TRIAL OF HIGH AND LOW DOSES OF MAGNESIUM SULFATE FOR ACUTE TOCOLYSIS
At the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. Although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. In this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. One-hundred patie...
متن کاملTMPyP4 promotes cancer cell migration at low doses, but induces cell death at high doses
TMPyP4 is widely considered as a potential photosensitizer in photodynamic therapy and a G-quadruplex stabilizer for telomerase-based cancer therapeutics. However, its biological effects including a possible adverse-effect are poorly understood. In this study, whole genome RNA-seq analysis was used to explore the alteration in gene expression induced by TMPyP4. Unexpectedly, we find that 27.67%...
متن کاملReview: multiple daily doses of antidepressants are not more effective than single daily doses.
Data extraction Data were extracted on study characteristics, drug regimen, sample size, compliance, mean baseline rating on depression scales, and percentage change at end point. Treatment effects were calculated and weighted in a meta-analysis. 3 different weights were used for each treatment effect to reflect 3 different assumptions about the correlation between baseline and follow up depres...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 2002
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(02)02301-4